Power, L. A., Clayton, A. D., Reynolds, W. R., Hose, D. R. J., Ainsworth, C., Chamberlain, T. W., Nguyen, B. N., Bourne, R. A., Kapur, N., Blacker, A. J., “Selective separation of maines from conitnuous processes using automated pH controlled extraction.” React. Chem. Eng., 2021, Accepted Article (DOI: 10.1039/D1RE00205H)

Quintana-Najera, J., Blacker, A. J., Fletcher, L. A., Ross, A. B. “The effect of augmentation of biochar and hydrochar in anaerobic digestion of a model substrate” BIORESOUR. TECHNOL., 2021, 321, 124494 (DOI: 10.1016/j.biortech.2020.124494)

Kwan, M. H. T., Breen, J.,  Bowden, M., Conway, L., Crossley, B., Jones, M. F., Munday, R., Pokar, N. P. B., Screen, T., Blacker, A. J. “Continuous Flow Chiral Amine Racemization Applied to Continuously Recirculating Dynamic Diastereomeric Crystallizations” J. ORG. CHEM., 2021, 86, 2458-2473 (DOI: 10.1021/acs.joc.0c02617)

Taylor C. J., Baker A., Chapman M. R., Reynolds W. R., Jolley K. E., Clemens G., Smith G. E., Blacker A. J., Chamberlain T. W., Christie S. D. R., Taylor B. A., Bourne, R. A. “Flow Chemistry for process optimisation using design of experiments” J. FLOW CHEM., 2021, (DOI: 10.1007/s41981-020-00135-0)

Climent Barba F., Chacón M. G., Reynolds W. R., Puri D. J., Bourne R. A., Blacker, A. J. (2021) Improved conversion of residual MSW biomass waste to sugars using online process monitoring and integrated contamination control. BIORESOUR. TECHNOL., 13, 100612 (DOI:

Cooksey J. P., Saidi O., Williams J. M. J., Blacker A. J., Marsden S. P. (2021) Oxidative Pictet-Spengler cyclisation through acceptorless iridium-catalysed dehydrogenation of tertiary amines. TETRAHEDRON, 78, 131785 (DOI:

Kwan, M. H. T., Pokar, N. P. B., Good, C., Jones, M. F., Munday, R., Screen, T., Blacker, A. J. “Deactivation mechanism of iodo-iridium catalysts in chiral amine racemization.” TETRAHEDRON, 2021, 80, 131823 (DOI:


Guan F., Kapur N., Sim L., Taylor C. J., Wen J., Zhang X., Blacker A. J. (2020) A universal reactor platform for batch and flow: application to homogeneous and heterogeneous hydrogenation. REACT. CHEM. ENG., 5, 1903-1908 (DOI: 10.1039/D0RE00061B)

Bayana M., Blacker A. J., Clayton A. D., Jolley K. E., Labes R., Taylor C. J., Reynolds W. (2020) A practical experiment to teach students continuous flow and physico-chemical methods: acetylation of ethylene diamine in liquid bi-phase. J. FLOW CHEM., (DOI: 10.1007/s41981-020-00114-5)

Holt C. A., Cottyn B., Baumberger S., Kovacs-Schreiner K., Blacker A. J. (2020) High throughput analysis of lignin by agarose gel electrophoresis. J. AGRIC. FOOD CHEM.,  6848, 14297-14306 (DOI: 10.1021/acs.jafc.0c06308)

Boobier S., Hose D. R. J., Blacker A. J., Nguyen B. (2020) Machine Learning with Physicochemical Relationships: Solubility Prediction in Organic Solvents and Water.” NATURE COMM., 11, 5753 (DOI: 10.1038/s41467-020-19594-z)

Clayton A. D., Power L. A., Reynolds W., Ainsworth C., Hose D. R. J.,  Jones M. F., Chamberlain T. W., Blacker A. J., Bourne, R. A. (2020) Self-Optimising Reactive Extractions: Towards the Efficient Development of Multi-Step Continuous Flow Processes. J. FLOW CHEM., 10, 199-206 (DOI:  10.1007/s41981-020-00086-6)

Clayton A. D., Schweidtmann A. M., Clemens G., Manson J. A., Taylor C. J., Niño C. G., Chamberlain T. W., Kapur N., Blacker A. J., Lapkin A. A., Bourne R. A. (2020) Automated Self-Optimisation of Multi-Step Reaction and Separation Processes Using Machine Learning. CHEM. ENG. J., 384 , 123340 (DOI: 10.1016/j.cej.2019.123340)

Clayton A. D., R. Labes R., Blacker A. J. (2020) “Combination of chemocatalysis and biocatalysis in flow.” CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY., 26, 100378 (DOI: 10.1016/j.cogsc.2020.100378)


Kawakami Y., Borissova A., Chapman M.R., Goltz G., Koltsova E., Mitrichev I., Blacker A.J. (2019) Continuous Flow Asymmetric Transfer Hydrogenation with Long Catalyst Lifetime and Low Metal Leaching. EUR. J. ORG. CHEM., 45, 7499-7505 (DOI: 10.1002/ejoc.201901547)

Cosgrove S. C., Mattey A. P., Riese M., M. R. Chapman, W. R. Birmingham, A. J. Blacker, N. Kapur, N. J. Turner, S. L. Flitsch (2019) Biocatalytic Oxidation in Continuous Flow for the Generation of Carbohydrate Dialdehydes. ACS CATALYSIS., 11658-11662 (DOI: 10.1021/acscatal.9b04819)

González N.C., Kapur N., King M-F., de Boer G., Blacker A.J., Bourne R., Thompson H. (2019) Computational fluid dynamic enabled design optimisation of miniaturised continuous oscillatory baffled reactors in chemical processing. INT. J. COMUT. FLUID DYN., 317-331  (DOI: 10.1080/10618562.2019.1683169)

Cooksey J. P., Kocienski P. J., Blacker A. J. (2019) A scalable process for the synthesis of 1,2-dialkyldiselanes and 1-alkaneselenols. ORG. PROC. RES. DEV.,  2571-2575 (DOI: 10.1021/acs.oprd.9b00380)

Manson J. A., Clayton A. D., Gonzalez Niño C., Labes R., Chamberlain T. W., Blacker A. J., Kapur N., Bourne R. A.(2019) A Hybridised Optimisation of an Automated Photochemical Continuous Flow Reactor. CHIMIA,  817 (DOI: 10.2533/chimia.2019.841)


Jolley, K. E., Chapman, M. R.,  Blacker, A. J. (2018) A general and atom-efficient continuous-flow approach to prepare amines, amides and imines via reactive N-chloramines. BEILSTEIN J. ORG. CHEM., 14, 2220-2228 (DOI: 10.3762/bjoc.14.196 )

Blacker, A. J., Moran-Malagon, G., Powell, L., Reynolds, W., Stones, R., Chapman, M. R. (2018) Development of an SnAr reaction: a practical and scalable strategy to sequester and remove HF. ORG. PROC. RES. DEV., 22 (9), 1086-1091(DOI: 10.1021/acs.oprd.8b00090)

Chapman, M. R.,  Cosgrove, S. C., Turner, N. J., Kapur, N., Blacker, A. J. (2018) Highly productive oxidative biocatalysis in continuous flow by enhancing the aqueous equilibrium solubility of oxygen. ANGEW. CHEM. INT. ED.,  57 (33), 10535-10539 (DOI: 10.1002/anie.201803675)


Jolley, K. E., Nye, W., González Niño, C., Kapur, N., Rabion, A., Rossen, K., Blacker, A. J. (2017) Highly productive continuous flow synthesis of di- and tripeptides in water. ORG. PROC. RES. DEV., 2017, 21(10), 1557-1565 (DOI: 10.1021/acs.oprd.7b00214)

Chapman, M. R., Kwan, M. H., King, G., Jolley, K. E., Hussain, M., Hussain, S., Salama, I. E., Gonzalez Nino, C., Thompson, L. A., Bayana, M. E., Clayton, A., Nguyen, B. N., Turner, N. J., Kapur, N., and Blacker, A. J. (2017) A simple and versatile laboratory scale CSTR for multiphasic continuous-flow chemistry and long residence times. ORG. PROC. RES. DEV., 21, 1294-1301 DOI: 10.1021/acs.oprd.7b00173

Marsden, S. P., McGowan, P. C., Lanaro, R., and Blacker, A. J. (2017) Preparation and use of transition metal complexes WO2017103623 (A1)

Hugentobler, K. G., Rasparini, M., Thompson, L. A., Jolley, K. E., Blacker, A. J. and Turner, N. J. (2017) Comparison of a batch and flow approach for the lipase catalysed resolution of a cyclopropanecarboxylate ester; a key building block for the synthesis of ticagrelor. ORG. PROCESS RES. DEV., 21, 195-199 DOI:10.1021/acs.oprd.6b00346


Zhao, Y., King, G., Kwan, M. H. T., Blacker, A. J. (2016) A mild and selective method for the catalytic hydrodeoxygenation of cyanurate activated phenols in multiphasic continuous flow. ORG. PROC. RES. DEV., 2012-2016 DOI: 10.1021/acs.oprd.6b00314

Sambiagio, C., Munday, R. H., Blacker, A. J., Marsden, S. P., McGowan, P. C. (2016) Green alternative solvents for the copper-catalysed arylation of phenols and amides. RSC ADV., 70025-70032. doi: 10.1039/C6RA02265K

Chapman, M. R., Kwan, M. H. T., King, G. E., Kyffin, B. A., Blacker, A. J., Willans, C. E., Nguyen, B. N. (2016) Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions. GREEN CHEM., 4623-4627. doi: 10.1039/C6GC01601D

Holmes, N., Akien, G. R., Blacker, A. J., Woodward, R. L., Meadows, R. E., Bourne, R. A. (2016) Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor. REACT. CHEM. ENG., 366-371. doi: 10.1039/C6RE00059B

Lucas, S. J., Lord, R. M., Basri, A. M., Allison, S. A., Phillips, R. M.,  Blacker, J., McGowan, P. C. (2016) Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes, DALTON TRANS., 2016, 6812-6815. doi: 10.1039/C6DT00186F

Holmes, N., Akien, G. R., Savage, R. J. D., Stanetty, C., Baxendale, I. R., Blacker, A. J., Taylor, B. A., Woodward, R. L. Meadows, R. E., Bourne, R. A. (2016). Online Quantitative Mass Spectrometry for the Rapid Adaptive Optimisation of Automated Flow Reactors. REACT. CHEM. ENG., 2016, 1, 96-100. doi: 10.1049/C5RE00083A


Blacker, A. J., Jolley, K. E. (2015). Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors. BEILSTEIN J. ORG. CHEM, 2408-2417. doi: 10.3762/bjoc.11.262

Sherborne, G. J., Chapman, M. R., Blacker, A. J., Bourne, R. A., Chamberlain, T. W., Crossley, B. D., Lucas, S. J., McGowan, P. C., Newton, M. A., O Screen, T. E., Thompson, P., Willans, C. E., Nguyen, B. N. (2015). Activation and Deactivation of a Robust Immobilizes Cp*Ir-Transfer Hydrogenation Catalyst: A Multielement in situ X-ray Absorption Spectroscopy Study. J AM. CHEM. SOC., 4151-4157. doi: 10.1021/ja512868a


Rodríguez-Bárzano, A., Fonseca, J. D. A., Blacker, A. J., McGowan, P. C (2014). Ruthenium Halide Complexes as N-Alkylation Catalysts. EUR. J. INORG. CHEM., 1974–1983. doi: 10.1002/ejic.201400117

Sambiagio, C., Marsden, S. P., Blacker, A. J., McGowan, P. C (2014). Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development. CHEM. SOC. REV., 43, 3525-3550. doi: 10.1039/C3CS60289C


Rodríguez-Bárzano, A., Blacker, A. J., McGowan, P. C (2013). Synthesis and characterisation of tetramethylfulvene complexes of ruthenium. DALTON TRANS., 42, 16669. doi: 10.1039/c3dt52747f

Lucas, S. J., Crossley, B. D., Pettman, A. J., Vassileiou, A. D., Screen, T. E. O., Blacker, A J., McGowan, P (2013). A Robust Method to Heterogenise and Recycle Group 9 Catalysts. CHEM. COMMUN., 49, 5562-5564. doi: 10.1039/c3cc42550a

Page, P. C. B., Farah, M. M., Buckley, B. R., Elsegood, M. R. J., & Blacker, A. J. (2013). Novel biphenyl organocatalysts for iminium ion-catalyzed asymmetric epoxidation. TETRAHEDRON, 69, 758-769.  doi: 10.1016/j.tet.2012.10.076


Blacker, A. J., Roy, M., Hariharan, S., Headley, C., Upare, A., Jagtap, A., Kadam, N. (2011). Convenient Method for Synthesis of N-Protected alpha-Amino Epoxides: Key Intermediates for HIV Protease Inhibitors. ORG. PROCESS RES. DEV., 15(2), 331-338. doi:10.1021/op100174


Saidi, O., Bamford, M. J., Blacker, A. J., Lynch, J., Marsden, S. P., Plucinski, Williams, J. M. J. (2010). Iridium-catalyzed formylation of amines with paraformaldehyde. TETRAHEDRON LETT, 51(44), 5804-5806. doi:10.1016/j.tetlet.2010.08.106

Saidi, O., Blacker, A. J., Lamb, G. W., Marsden, S. P., Taylor, J. E., & Williams, J. M. J. (2010). Borrowing Hydrogen in Water and Ionic Liquids: Iridium-Catalyzed Alkylation of Amines with Alcohols. ORG. PROCESS RES. DEV., 14(4), 1046-1049. doi:10.1021/op100024j

McConville, M., Blacker, J., & Xiao, J. L. (2010). Heck Reaction in Diols and Cascade Formation of Cyclic Ketals. SYNTHESIS, (2), 349-360. doi:10.1055/s-0029-1217139

Saidi, O., Blacker, A. J., Farah, M. M., Marsden, S. P., & Williams, J. M. J. (2010). Iridium-catalysed amine alkylation with alcohols in water. CHEM. COMMUN., 46(9), 1541-1543. doi:10.1039/b923083a

McConville, M., Ruan, J. W., Blacker, J., & Xiao, J. L. (2010). Synthesis of oxygen heterocycles by regioselective Heck reaction. ORG. BIOMOL. CHEM., 8(24), 5614-5619. doi:10.1039/c0ob00508h

Valera, F. E., Quaranta, M., Moran, A., Blacker, J., Armstrong, A., Cabral, J. T., Blackmond, D. G. (2010). The Flow’s the Thing … Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow. ANGEW. CHEM. INT. ED., 49(14), 2478-2485. doi:10.1002/anie.200906095


Blacker, A. J., Clot, E., Duckett, S. B., Eisenstein, O., Grace, J., Nova, A., Whitwood, A. C. (2009). Synthesis and structure of “16-electron” rhodium(III) catalysts fortransfer hydrogenation of a cyclic imine: mechanistic implications.. CHEM. COMMUN., (44), 6801-6803. doi:10.1039/b912943j

Blacker, A. J., Farah, M. M., Marsden, S. P., Saidi, O., & Williams, J. M. J. (2009). Oxidative conversion of amines into benzoxazoles using hydrogen transfer catalysis. TETRAHEDRON LETT., 50(45), 6106-6109. doi:10.1016/j.tetlet.2009.08.042

Blacker, A. J., Brown, S., Clique, B., Gourlay, B., Headley, C. E., Ingham, S., Thompson, G. (2009). A Low-Waste Process To Sertraline By Diastereomeric Crystal Resolution and Waste Isomer Racemisation. ORG. PROCESS RES. DEV., 13(6), 1370-1378. doi:10.1021/op900112f

Page, P. C. B., Buckley, B. R., Farah, M. M., & Blacker, A. J. (2009). Binaphthalene-Derived Iminium Salt Catalysts for Highly Enantioselective Asymmetric Epoxidation. EUR. J. ORG. CHEM., (20), 3413-3426. doi:10.1002/ejoc.200900252

Blacker, A. J., Farah, M. M., Hall, M. I., Marsden, S. P., Saidi, O., & Williams, J. M. (2009). Synthesis of benzazoles by hydrogen-transfer catalysis.. ORG. LETT., 11(9), 2039-2042. doi:10.1021/ol900557u

McConville, M., Saidi, O., Blacker, J., & Xiao, J. L. (2009). Regioselective Heck Vinylation of Electron-Rich Olefins with Vinyl Halides: Is the Neutral Pathway in Operation?. J. ORG. CHEM., 74(7), 2692-2698. doi:10.1021/jo802781m

Blacker, A. J., Duckett, S. B., Grace, J., Perutz, R. N., & Whitwood, A. C. (2009). Reactivity, Structures, and NMR Spectroscopy of Half-Sandwich Pentamethylcyclopentadienyl Rhodium Amido Complexes Relevant to Transfer Hydrogenation. ORGANOMETALLICS, 28(5), 1435-1446. doi:10.1021/om8009969

Saidi, O., Blacker, A. J., Farah, M. M., Marsden, S. P., & Williams, J. M. J. (2009). Selective Amine Cross-Coupling Using Iridium-Catalyzed “Borrowing Hydrogen” Methodology. ANGEW. CHEM. INT. ED., 48(40), 7375-7378. doi:10.1002/anie.200904028


Grigg, R., Blacker, J., Kilner, C., McCaffrey, S., Savic, V., & Sridharan, V. (2008). Stereoselective synthesis of chiral beta(2,3)-disubstituted-beta-amino acid derivatives using Pd/In transmetallation cascade processes. TETRAHEDRON, 64(35), 8177-8181. doi:10.1016/j.tet.2008.06.037

Page, P. C. B., Farah, M. M., Buckley, B. R., Blacker, A. J., & Lacour, J. (2008). Novel binaphthalene-amine catalysts for the asymmetric epoxidation of alkenes. SYNLETT, (9), 1381-1385. doi:10.1055/s-2008-1072592


Ikariya, T., & Blacker, A. J. (2007). Asymmetric transfer hydrogenation of ketones with bifunctional transition metal-based molecular. ACC. CHEM. RES., 40(12), 1300-1308. doi:10.1021/ar700134q

Page, P. C. B., Buckley, B. R., Barros, D., Blacker, A. J., Marples, B. A., & Elsegood, M. R. J. (2007). Asymmetric organocatalysis of epoxidation by iminium salts under non-aqueous conditions. TETRAHEDRON, 63(25), 5386-5393. doi:10.1016/j.tet.2007.04.066

Blacker, A. J., Stirling, M. J., & Page, M. I. (2007). Catalytic racemisation of chiral amines and application in dynamic kinetic resolution. ORG. PROCESS RES. DEV., 11(3), 642-648. doi:10.1021/op060233w

Stirling, M., Blacker, A. J., & Page, M. I. (2007). Chemoenzymatic dynamic kinetic resolution of secondary amines. TETRAHEDRON LETT., 48, 1247-1250. doi:10.1016/j.tetlet.2006.12.032

Page, P. C. B., Farah, M. M., Buckley, B. R., & Blacker, A. J. (2007). New chiral binaphthalene-derived iminium salt organocatalysts for asymmetric epoxidation of alkenes. J. ORG. CHEM., 72(12), 4424-4430. doi:10.1021/jo070255w

Books and Chapters

Blacker, J., Breen, J. R., Bourne, R. A., & Hone, C. A., (2016) The growing impact of continuous flow methods on the twelve principles of green chemistry. In L. Summerton, H. F. Sneddon, L. C. Jones & J. H. Clark (Eds.), Green and sustainable medicinal chemistry: methods, tools and strategies for the 21st century pharmaceutical industry. RSC Publishing

Blacker, J., & Williams, M. T. (2011). Pharmaceutical Process Development. RSC Publishing

Blaser, H. U., & Federsel, H. -J. R. (2011). Asymmetric Catalysis on Industrial Scale. Wiley-VCH.

Dunn, P., Wells, A., & Williams, M. T. (2010). Green Chemistry in the Pharmaceutical Industry. Wiley-VCH.

Blacker, A. J. (2007). Enantioselective Transfer Hydrogenations. In J. G. D. Vries, & C. J. Elsevier (Eds.), The Handbook of Homogeneous Hydrogenation (Vol. 1, pp. 1215-1244). Wiley VCH.